Biostimulators, also known as collagen stimulators, are injectable treatments designed to
enhance the body’s natural collagen production. Collagen, often referred to as the building
block of youthful skin, is a protein responsible for skin tightening and maintaining skin firmness,
elasticity and overall quality. As we age our natural collagen production decreases leading to
the development of wrinkles, fine lines and the loss of facial volume. Biostimulators step into
stimulating collagen over time restoring a more youthful appearance to the skin.

These aesthetic treatments typically contain biocompatible material such as poly-l- lactic acid
(PLLA), calcium hydroxylapatite (CAH), or hyaluronic acid (HA). When injected into the skin
biostimulators trigger a series of biological processes that stimulate collagen synthesis over
time. This gradual approach results in natural looking, natural production and rejuvenated
appearance to the skin’s texture, firmness and volume.

Two Types of Biostimulators

Biostimulators come in various forms, different types of biostimulators each offering a unique
approach to skin rejuvenation. Let’s take a closer look at two of the most popular options :

1) Radiesse
Radiesse is a dual action dermal filler and biostimulator, popular in cosmetic medicine for
addressing skin aging. Initially, it provides immediate volumisation using sodium
carboxymethylcellulose (CMC) to combat volume loss. As the CMC absorbs, Calcium
Hydroxylapatite (CaHa) micro spheres stimulate collagen production for sustained skin
rejuvenation.

Radiesse, an FDA approved injectable treatment for both facial correction and hand
augmentation, is ideal for mature patients. The CaHa micro spheres in a CMC gel carrier sculpt
facial contours and improve skin quality. Over time CaHa particles continue to boost
neocollagenesis, enhancing tissue regeneration and offering a naturally refreshed appearance.

Radius can be part of combination procedures with other biostimulators providing effective skin
firming and lifting. It addresses deep wrinkles, skin volume and hydration ensuring long-lasting
results and high patient satisfaction.

2) Ellanse
Ellanse is a collagen stimulating filler known for its immediate and long-lasting results, making it
a popular biostimulator in cosmetic medicine. It helps reverse facial aging, lift loose skin and
restore lost volume by boosting collagen production. Ellanse uses polycaprolactone (PCL)
microspheres in a carboxymethylcellulose (CMC) gel. The CMC gel offers immediate volume
restoration while the PCL microspheres stimulate new collagen over time. This dual action
addresses deep wrinkles and improves skin quality for over 24 months making it superior to
hyaluronic acid fillers.

Ellanse treats areas like the forehead, temples, cheeks, nasolabial folds and chin. The PCL
microspheres enhance collagen fibers and promote natural tissue regeneration leading to
significant long-term improvements in skin texture and volume this makes alarm say an effective
choice for those seeking long lasting natural looking results in skin rejuvenation and lifting.

The biostimulator treatment experience typically begins with a consultation with the doctor.
During this consultation, the doctor will assess your skin condition, discuss your goals and
concerns and develop a personalised treatment plan tailored to your needs.

On the day of your treatment, your doctor will cleanse the treatment area and apply either a
topical numbing cream or injection to ensure your comfort during the procedure. Once the skin
is numb, they will carefully inject the biostimulator solution into targeted areas of the face using
a fine needle or cannula.

The injection process is relatively quick and straightforward, with most treatments taking around
45 to 60 minutes to complete. Afterwards you may experience some minor swelling, bruising or
redness at the injection sites but these side effects typically subside within a few days.

After your collagen by stimulated treatment it’s essential to follow the post care instructions to
optimise your results and minimise any potential side effects. This may include avoiding
strenuous activities applying ice packs to reduce swelling and avoiding excessive sun exposure.

In the days and weeks following your treatment, you should start to notice gradual improved
skin texture, firmness and skin quality improvements. It’s important to be patient during this time
as biostimulator treatments work by stimulating collagen production which takes time to manifest
visible results.

In general most patients begin to notice improvements in their skin within a few weeks to
months after their initial treatment. However, full results may take several months to become
apparent as collagen production continues to increase.

Treatment time: 45-60 minutes
Analgesia:  Topical and Local
Downtime:  24 hours
Possible side effects:  Minor Bruising,Swelling or Redness
Follow up:  8 weeks
Results last:  2 years